禾樾生物官方商城

Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap^[1][2][3][4].

Cytochalasin D (3 和 10 μM；30 分钟) 导致 COS-7 细胞收缩和分枝，以及 F-肌动蛋白从长纤维转化为点状结构^[1]。
Cytochalasin D (0.3、1、3 和 10 μM；30 分钟) 浓度依赖性地降低 COS-7 细胞中肌动蛋白解聚的速率^[1]。
细胞松弛素 D (1 μM；NIH3T3 细胞) 破坏应力纤维，诱导 Yap 磷酸化，同时细胞保持原有区域并丢失核 Yap 定位^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

507.62

Solid

C₃₀H₃₇NO₆

22144-77-0

细胞松弛素D

Room temperature in continental US; may vary elsewhere.

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