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CAS No. : 815610-63-0
MCE 国际站:Ustekinumab
产品活性:Ustekinumab 是一种抗 IL-12/IL-23 的人源单克隆 IgG1κ 抗体。
作用靶点:<a related.html"="" style="margin: 0px; padding: 0px; list-style: none; font-size: inherit; font-family: revert; outline: none; transition: all 0.5s ease 0s; color: rgb(59, 168, 233); line-height: 28px; font-style: revert;">Interleukin Related
In Vitro: Ustekinumab is a human monoclonal antibody that prevents human IL-12 and IL-23 from binding to the IL-12Rβ1 receptor chain of IL-12 (IL-12Rβ1/β2) and IL-23 (IL-12Rβ1/23R) receptor complexes on the surface of natural killer cells and T-cells. Ustekinumab is a human IgG1 kappa (κ) monoclonal antibody against the IL-12/IL-23 p40 subunit that prevents its interaction with IL-12Rβ1, thereby blocking subsequent signaling. The FcRn affinities at pH 6.0 fell in a narrow range for all 11 antibodies. The equilibrium dissociation constant (KD) is calculated relative to Ustekinumab (Ustekinumab=1.0).
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