Ranibizumab

CAS No. : 347396-82-1

MCE 国际站：Ranibizumab

产品活性：Ranibizumab (RG-6321) 是一种人源化的抗 VEGF 单克隆抗体片段，能够识别所有 VEGF-A 亚型 (VEGF110，VEGF121，以及 VEGF165)。动物模型中，Ranibizumab 减缓视力丧失，并用于老年黄斑变性 (AMD) 的研究。

研究领域：<a tyrosine="" kinase="" rtk.html"="" style="margin: 0px; padding: 0px; list-style: none; font-size: inherit; font-family: revert; outline: none; transition: all 0.5s ease 0s; color: rgb(59, 168, 233); line-height: 28px; font-style: revert;">Protein Tyrosine Kinase/RTK

作用靶点：VEGFR

In Vitro: Ranibizumab (RG-6321) is a humanized anti-VEGF monoclonal antibody fragment (IgG antigen-binding fragment (Fab-Y0317). Ranibizumab (0.0625-0.25 mg/ml; 72 hours) results in increased necrosis and apoptosis at in rat retinal cell cultures.

In Vivo: Studies in monkeys demonstrates that after a single intravitreal administration, Ranibizumab can distribute rapidly to the retina (6–24 h). Ranibizumab can rapidly penetrate through the retina to reach the choroid, just 1 h after intravitreal administration in rabbits.
In a study comparing the pharmacokinetics of 0.5 mg of intravitreal Ranibizumab with 1.25 mg of intravitreal Bevacizumab in the rabbit, the vitreous half-life of Ranibizumab is 2.88 days, shorter than the Bevacizumab half-life of 4.32 days. Peak concentrations in the aqueous humor of the treated eye at 3 days following treatment are 37.7 μg/ml for Bevacizumab and 17.9 μg/ml for Ranibizumab, respectively.

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