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CAS No. : 331731-18-1
MCE 国际站:Adalimumab (anti-TNF-α)
产品活性:Adalimumab (anti-TNF-α) 是一种人源的单克隆 IgG1 抗体,靶向肿瘤坏死因子α (TNF-α)。
研究领域:Apoptosis
作用靶点:TNF Receptor
In Vitro: Treatment of HUVECs with Adalimumab for up to 12 hours shows no adverse effect on their cell viability, even with a 10-fold higher concentration of Adalimumab (anti-TNF-α) than used in this study.
In Vivo: The elimination half-life (t1/2) of Adalimumab (anti-TNF-α) is long (~20 days). The enriched fluorescent-labelled adalimumab (anti-TNF-α) is observed mainly in major Oil red O-positive lesions documenting good tissue penetration of the drug into the atherosclerotic plaque, without background fluorescence of the vessel wall after vehicle control injection into hypercholesterolemic Ldlr-/- mice.
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